Obstructive sleep apnea related to presence, coronary plaque publicity

November 16, 2021

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A new study highlights an independent association between obstructive sleep apnea and the presence and of coronary plaque, suggesting that it may be a risk factor for coronary events.

The researchers conducted a cross-sectional study at a single center that enrolled 692 adults (mean age 55.1 years; 71% men) who underwent sleep monitoring and coronary CT angiography at Beijing Anzhen Hospital from September 2015 to April 2019. One hundred and twenty patients (17.3%) received a polysomnograph and 572 (82.7%) received a respiratory polygraph.

The data were from Lu M, et al. Breast. 2021; doi: 10.1016 / j.chest.2021.07.040.

Patients with to severe OSA were more likely to have coronary plaques (P = .037) and were more likely to have a non-calcified plaque component (P = .032) and a non-calcified low-density plaque component (P.) = .03), according to the researchers.

Both the apnea-hypopnea index and oxygen desaturation index have been linked to the presence of coronary plaques, a non-calcified plaque component, and a non-calcified low-density plaque component (p <0.05 for all), the researchers reported.

In multivariable linear regression models, to severe OSA was also associated with non-calcified plaque volume (P = .042) and non-calcified low-density plaque volume (P = .011).

In addition, the researchers identified the apnea-hypopnea index (P = 0.015), the oxygen desaturation index (P = 0.005), and the percentage of nighttime hours with less than 90% oxygen saturation (P = 0.017) as significant predictors of low-density des not calcified plaque volume.

When the researchers compared patients with no OSA or with mild OSA, patients with severe OSA had a higher total volume of coronary plaque (P = 0.017), a volume of uncalcified plaque (P = .036), and a volume of uncalcified low-density plaque (P = 0.013.). ).

“Our results suggest an increased to high-risk plaques in patients with to severe OSA, which may explain the increased risk of [acute coronary syndrome] in these patients, ”Mi Lu, MD, from the Department of Otorhinolaryngology and Head and Neck Surgery at Sleep Medical Center, Beijing Anzhen Hospital, Capital Medical University and the Key Laboratory of Upper Airway Dysfunction-Related Cardiovascular Diseases at the Beijing Institute of Heart, Lung and Blood Vascular Diseases and colleagues wrote in Chest. “However, larger outcome studies are needed to confirm this hypothesis.”

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