For many people newly diagnosed with sleep apnea, starting CPAP therapy can feel overwhelming. The mask feels strange, the airflow feels intense, and discomfort often leads to one outcome sleep specialists know all too well: patients stop using the device.
But what if one small setting change—one that goes against industry norms—could make CPAP therapy far more comfortable for new users?
That’s the question sleep specialist William H. Noah, MD, has been exploring, and his findings are prompting clinicians across the country to rethink how CPAP therapy is prescribed.
A Counterintuitive Idea
Dr. Noah, medical director of Sleep Centers of Middle Tennessee, has been quietly experimenting with a simple adjustment: using the “full-face mask” setting on CPAP machines for patients who are actually wearing nasal pillow masks.
At first glance, this seems backward. CPAP devices are programmed with mask-specific algorithms designed to compensate for airflow resistance. Because nasal pillow masks have small openings, machines typically deliver higher inspiratory pressure when that setting is selected.
But according to Noah, that compensation may be doing more harm than good.
“The full-face setting has been unanimous so far,” Noah says of his early results. “We haven’t had anyone who thought the nasal pillow setting was more comfortable.”
Why Nasal Pillows Can Feel Too Harsh
Mask compensation algorithms were designed to overcome resistance differences between mask types. A former CPAP manufacturer employee involved in developing these algorithms explains it this way:
- Full-face masks have minimal resistance
- Nasal masks have moderate resistance
- Nasal pillow masks have the most resistance
To offset that resistance, CPAP devices increase inspiratory pressure for nasal pillows. But Noah believes that adjustment leads to excessive airflow velocity, creating an uncomfortable “jetting” effect in the nostrils.
“All it did was decrease adherence for the nasal pillow mask,” Noah says. Patients often describe feeling like they’re choking, suffocating, or being blasted with air—sensations that quickly lead them to remove the mask during the night.
Testing the Theory
Noah began informally testing his hypothesis among staff and CPAP-naive patients at his sleep centers. Participants tried nasal pillow masks using both the nasal pillow setting and the full-face setting.
The result? Every participant reported greater comfort with the full-face setting.
Importantly, these findings applied primarily to new CPAP users. Long-term users may already be accustomed to higher pressures and may not experience the same benefit. Noah is now developing a formal clinical trial, currently awaiting Institutional Review Board approval.
Does Comfort Compromise Therapy?
One of the biggest concerns with changing mask settings is whether it might reduce treatment effectiveness. Noah argues the opposite.
He is part of a growing group of sleep medicine experts who believe expiratory pressure—not inspiratory pressure—is the key therapeutic component of CPAP. Research suggests expiratory pressure should be maintained, while inspiratory pressure can often be lower without sacrificing efficacy.
In other words, increasing inspiratory pressure for nasal pillow masks may not improve therapy at all—it may simply make it harder to tolerate.
By selecting the full-face setting, the machine no longer adds extra inspiratory pressure, resulting in a gentler, more comfortable experience.
A Shift in Clinical Thinking
Noah’s presentations have resonated with other sleep specialists.
After hearing Noah speak at a Kentucky Sleep Society meeting, Abinash Joshi, MD, medical director of sleep medicine at Owensboro Health, immediately recognized the connection to his own patients’ complaints.
“That explains a lot,” Joshi says. “That jetting effect through those small nasal pillow holes is very harsh. Patients feel intolerant, rip the mask off, and say they’re suffocating.”
Joshi now routinely uses the full-face setting for patients on nasal pillow masks—and reports improved comfort.
Similarly, Robert Farney, MD, a clinical professor at the University of Utah College of Medicine, has adjusted his approach, rarely enabling expiratory pressure relief and avoiding nasal pillow algorithms that unnecessarily increase inspiratory pressure.
“Very few clinicians are aware of the undesired effects of programming CPAP devices for nasal pillows,” Farney says.
Looking Back—and Forward
Interestingly, Noah recalls prescribing large numbers of nasal pillow masks in the early 2000s—before mask compensation algorithms existed. Patients tolerated them well and wore them consistently.
Once those algorithms were introduced, nasal pillow adherence declined, and full-face mask use increased.
“We’ve just seen less adherence since that time,” Noah says.
Today, about 95% of patients at his sleep centers receive nasal pillow masks—but with carefully selected machine settings.
Why Mask Selection Matters More Than Ever
The American Thoracic Society has also highlighted the importance of proper mask selection, noting an overuse of full-face masks as the default choice. Studies show higher patient satisfaction and better outcomes with nasal interfaces when pressure and adherence are similar.
According to Robert Miller, RPSGT, vice president of sleep business at Apria Healthcare, Noah’s work raises an important point for the industry.
“The industry really needs to take notice,” Miller says. “Ultimately, we’re all trying to achieve better outcomes and higher patient acceptance.”
A Simple Change with Big Potential
Noah believes CPAP technology itself needs to be reexamined. But for now, something as simple as flipping a setting may help new patients ease into therapy—and stick with it.
And in the world of sleep medicine, better adherence often means better health.
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